ABL is second to none in its ability to meet urgent customer needs, often providing modified peptides which have never been synthesised before. Our laboratories are equipped with fully automated synthesisers allowing multiple peptide synthesis. Fmoc, t-Boc and Cbz chemistries are routinely used in our laboratory and to ensure success, difficult and modified peptide sequences and those which typically fail on synthesisers are produced manually by our expert chemists.

To ensure product quality, HPLC analysis is always carried out by reverse phase HPLC using Vydac columns. Peptide purity is determined by calculating the relative area of the main product peak in the sensitive UV region (218 nm). A certificate of analysis is supplied with each peptide and includes a mass spectral and HPLC analysis to ensure product integrity and purity. We believe our qualities and efficiency of service are unmatched by any other supplier.

With many years of practical (Peptide Products est 1989) and research experience, we have particular expertise with modified and difficult-to-synthesise peptides. Examples of modifications of peptides are diverse and ABL routinely tailor quotes for unusual peptides. To deliver quality solutions, ABL utilise a wide range of chemistries including both solid and solution phase technologies along with tactical protecting strategies. For instance, the in-house availability of Fmoc, t-Boc and Cbz approaches allows great versatility for site-specific modifications.

ABL offers a comprehensive fluorescent labelling service which includes expert technical advice on the selection of the correct fluorescent label for your application. In addition to our usual QA, we also include excitation and emission spectra for each product. An extensive range of fluorophores is now available to replace radioactive labels. Whereas radiolabelled peptides require special handling procedures and are expensive, fluorescent labels can be more readily introduced during chain assembly or post-synthetically in a cost-effective manner.